Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance.

ABSTRACT:

Background

Ketone bodies (KBs) are an alternative energy supply for brain functions when glucose is limited. The most abundant ketone metabolite, 3-β-hydroxybutyrate (BOHBUT), has been suggested to prevent or delay cognitive impairment, but the evidence remains unclear. We triangulated observational and Mendelian randomization (MR) studies to investigate the association and causation between KBs and cognitive function.

Methods

In observational analyses of 5506 participants aged ≥ 45 years from the Whitehall II study, we used multiple linear regression to investigate the associations between categorized KBs and cognitive function scores. Two-sample MR was carried out using summary statistics from an in-house KBs meta-analysis between the University College London-London Schoo

SUBMITTER: Sae-Jie W 

PROVIDER: S-EPMC10478491 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature