Non-canonical two-step biosynthesis of anti-oomycete indole alkaloids in Kickxellales.

ABSTRACT:

Background

Fungi are prolific producers of bioactive small molecules of pharmaceutical or agricultural interest. The secondary metabolism of higher fungi (Dikarya) has been well-investigated which led to > 39,000 described compounds. However, natural product researchers scarcely drew attention to early-diverging fungi (Mucoro- and Zoopagomycota) as they are considered to rarely produce secondary metabolites. Indeed, only 15 compounds have as yet been isolated from the entire phylum of the Zoopagomycota.

Results

Here, we showcase eight species of the order Kickxellales (phylum Zoopagomycota) as potent producers of the indole-3-acetic acid (IAA)-derived compounds lindolins A and B. The compounds are produced both under laboratory conditions and in the natural soil habitat sugg

SUBMITTER: Rassbach J 

PROVIDER: S-EPMC10478498 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature