Lipid profile with eslicarbazepine acetate and carbamazepine monotherapy in adult patients with newly diagnosed focal seizures: post hoc analysis of a phase III trial and open-label extension study.

ABSTRACT:

Background

Antiseizure medications can have negative effects on plasma lipid levels.

Objectives

To evaluate plasma lipid changes in patients with newly diagnosed focal epilepsy treated with eslicarbazepine acetate (ESL) or controlled-release carbamazepine (CBZ-CR) monotherapy during a phase III, randomized, double-blind (DB) trial and 2 years of ESL treatment in an open-label extension (OLE).

Design

Post hoc analysis of a phase III trial and OLE study.

Methods

Proportions of patients with elevated levels of total cholesterol and low-density lipoprotein (LDL) cholesterol were assessed at DB baseline, OLE baseline (last visit of DB trial), and end of OLE.

Results

A total of 184 patients received ESL monotherapy during the OLE: 96 received ESL monoth

SUBMITTER: Trinka E 

PROVIDER: S-EPMC10478566 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature