Exploratory mass spectrometry of cerebrospinal fluid from persons with autopsy-confirmed LATE-NC.

ABSTRACT:

Background

Common neuropathologies associated with dementia include Alzheimer's disease neuropathologic change (ADNC) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC). Biofluid proteomics provides a window into the pathobiology of dementia and the information from biofluid tests may help guide clinical management.

Methods

Participants were recruited from a longitudinal cohort of older adults at the University of Kentucky AD Research Center. A convenience sample of clinically obtained lumbar puncture cerebrospinal fluid (CSF) samples was analyzed from 29 older adults that had autopsy confirmation of the presence or absence of LATE-NC. Nine of the participants had autopsy-confirmed LATE-NC. Antemortem CSF specimens were analyzed in two

SUBMITTER: Gal J 

PROVIDER: S-EPMC10479397 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature