Thermoring Basis for the Heat Inactivation in TRPV1.

ABSTRACT: Transient receptor potential vanilloid-1 (TRPV1) in mammals exhibits the temperature-dependent inactivation in response to repeated or constant heat stimuli. However, the underlying structural factors or motifs are unresolved. In this computational study, the graph theory-based grid thermodynamic model was employed to reveal how the temperature-dependent non-covalent interactions as identified in the 3D structures of TRPV1 could develop a systemic fluidic grid-like mesh network with topological grids constrained as the thermo-rings to govern the heat inactivation from open and pre-open closed states in different temperature ranges. The results showed that the heat-evoked melting of three biggest grids in different gating states was responsible for the TRPV1 activity starting at 43°C and pe

SUBMITTER: Wang G 

PROVIDER: S-EPMC10479453 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature