Broadcasters, receivers, functional groups of metabolites and the link to heart failure using polygenic factors.

ABSTRACT: In a prospective study with records of heart failure (HF) incidence, we present metabolite profiling data from individuals without HF at baseline. We uncovered the interconnectivity of metabolites using data-driven and causal networks augmented with polygenic factors. Exploring the networks, we identified metabolite broadcasters, receivers, mediators, and subnetworks corresponding to functional classes of metabolites, and provided insights into the link between metabolomic architecture and regulation in health. We incorporated the network structure into the identification of metabolites associated with HF to control the effect of confounding metabolites. We identified metabolites associated with higher or lower risk of HF incidence, the associations that were not confounded by the other me

SUBMITTER: Yazdani A 

PROVIDER: S-EPMC10479558 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature