Acute Kidney Injury and Intestinal Dysbiosis.

ABSTRACT: Within the multiple communication pathways of the intestine-kidney axis, one of the most important pathways is the interaction between the commensals of the intestinal microbiome, through the production of short-chain fatty acids, and the segments of the nephron. These interactions maintain a perfect environmental balance. During AKI, there are negative repercussions in all organs, and the systemic interconnection is related in part to the intense inflammation and the uremic environment that this syndrome generates. For example, in the intestine, the microbiome is severely affected, with a decrease in benign bacteria that promote anti-inflammatory effects and an increase in negative, pro-inflammatory bacteria. This scenario of intestinal dysbiosis widens the inflammatory loop that favors w

SUBMITTER: Chavez-Iniguez JS 

PROVIDER: S-EPMC10479571 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature