Urinary sodium excretion is low prior to acute kidney injury in patients in the intensive care unit

ABSTRACT:

Background

The incidence of acute kidney injury (AKI) is high in intensive care units (ICUs), and a better understanding of AKI is needed. Early chronic kidney disease is associated with urinary concentration inability and AKI recovery with increased urinary solutes in humans. Whether the inability of the kidneys to concentrate urine and excrete solutes at appropriate levels could occur prior to the diagnosis of AKI is still uncertain, and the associated mechanisms have not been studied.

Methods

In this single-center prospective observational study, high AKI risk in ICU patients was followed up for 7 days or until ICU discharge. They were grouped as “AKI” or “No AKI” according to their AKI status throughout admission. We collected daily urine samples to measure solute con

SUBMITTER: de Morais D 

PROVIDER: S-EPMC10479577 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature