Which Is a Better Predictor of GFR Decline: 24-h Urine Protein or 24-h Protein–Creatinine Ratio? An Exploration of the MDRD Study Data

ABSTRACT:

Background

Proteinuria is a known risk factor for progression of chronic kidney disease. Proteinuria magnitude can be estimated by measuring spot urine protein-to-creatinine ratio (least accurate), 24-h urine collection for protein (24 P), or 24-h protein–creatinine ratio (24 PCR). The MDRD study found that 24 P measured at baseline was the strongest single predictor of the rate of GFR decline during study follow-up. However, predictive powers of 24 P and 24 PCR have not been compared in the literature. The current study addresses this question using the MDRD cohort data.

Methods

The study is a retrospective analysis of prospectively collected data from the MDRD cohort using simple and multiple regression models. Slope of measured GFR (mGFR) over time was used as the resp

SUBMITTER: Ayoub I 

PROVIDER: S-EPMC10479620 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature