Genetic susceptibility to cognitive decline following craniospinal irradiation for pediatric central nervous system tumors.

ABSTRACT:

Background

Survivors of pediatric central nervous system (CNS) tumors treated with craniospinal irradiation (CSI) exhibit long-term cognitive difficulties. Goals of this study were to evaluate longitudinal effects of candidate and novel genetic variants on cognitive decline following CSI.

Methods

Intelligence quotient (IQ), working memory (WM), and processing speed (PS) were longitudinally collected from patients treated with CSI (n = 241). Genotype-by-time interactions were evaluated using mixed-effects linear regression to identify common variants (minor allele frequency > 1%) associated with cognitive performance change. Novel variants associated with cognitive decline (P < 5 × 10-5) in individuals of European ancestry (n = 163) were considered replicated if they demonstr

SUBMITTER: Brown AL 

PROVIDER: S-EPMC10479777 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature