Influenza A virus infection and pathology in nasal and periocular tissues after ocular inoculation in ferrets.

ABSTRACT: Influenza A viruses (IAV) cause mammalian infections following several transmission routes. Considering the anatomic proximity and connection between the nasopharynx and periocular tissues, there is a need to understand the dynamics of virus spread between these sites following both respiratory and nonrespiratory viral transmission. We examined virus distribution and associated inflammation within nasal and periocular tissues during the acute phase of H1N1 IAV infection in ferrets following intranasal or ocular inoculation. Ocular and intranasal inoculations with IAV caused comparable viral antigen distribution and inflammation in the nasal passages, though infection kinetics and magnitude differed by inoculation route. Ocular inoculation was associated with inflammation in the conjunctiva

SUBMITTER: Gary JM 

PROVIDER: S-EPMC10479928 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature