Spike Protein Fragments Promote Alzheimer's Amyloidogenesis.

ABSTRACT: Alzheimer's disease (AD) is a major cause of dementia inducing memory loss, cognitive decline, and mortality among the aging population. While the amyloid aggregation of peptide Aβ has long been implicated in neurodegeneration in AD, primarily through the production of toxic polymorphic aggregates and reactive oxygen species, viral infection has a less explicit role in the etiology of the brain disease. On the other hand, while the COVID-19 pandemic is known to harm human organs and function, its adverse effects on AD pathobiology and other human conditions remain unclear. Here we first identified the amyloidogenic potential of ¹⁰⁵⁸HGVVFLHVTYV¹⁰⁶⁸, a short fragment of the spike protein of SARS-CoV-2 coronavirus. The peptide fragment was found to be toxic and displayed

SUBMITTER: Cao S 

PROVIDER: S-EPMC10480042 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature