Targeting Clic1 for the treatment of obesity: A novel therapeutic strategy to reduce food intake and body weight.

ABSTRACT:

Objective

Despite great advances in obesity therapeutics in recent years, there is still a need to identify additional therapeutic targets for the treatment of this disease. We previously discovered a signature of genes, including Chloride intracellular channel 1 (Clic1), whose expression was associated with drug-induced weight gain, and in these studies, we assess the effect of Clic1 inhibition on food intake and body weight in mice.

Methods

We studied the impact of Clic1 inhibition in mouse models of binge-eating, diet-induced obese mice and genetic models of obesity (Magel2 KO mice).

Results

Clic1 knockout (KO) mice ate significantly less and had a lower body weight than WT littermates when either fed chow or high fat diet. Furthermore, pharmacological inhibition o

SUBMITTER: Zapata RC 

PROVIDER: S-EPMC10480059 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature