Structural analysis of peptide binding to integrins for cancer detection and treatment.

ABSTRACT: Integrins are cell receptors involved in several metabolic pathways often associated with cell proliferation. Some of these integrins are downregulated during human physical development, but when these integrins are overexpressed in adult humans, they can be associated with several diseases, such as cancer. Molecules that specifically bind to these integrins are useful for cancer detection, diagnosis, and treatment. This review focuses on the structures of integrin-peptidic ligand complexes to dissect how the binding occurs and the molecular basis of the specificity and affinity of these peptidic ligands. Understanding these interactions at the molecular level is fundamental to be able to design new peptides that are more specific and more sensitive to a particular integrin. The integrin c

SUBMITTER: Urquiza M 

PROVIDER: S-EPMC10480133 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature