Quantifying trial-by-trial variability during cortico-cortical evoked potential mapping of epileptogenic tissue.

ABSTRACT:

Objective

Measuring cortico-cortical evoked potentials (CCEPs) is a promising tool for mapping epileptic networks, but it is not known how variability in brain state and stimulation technique might impact the use of CCEPs for epilepsy localization. We test the hypotheses that (1) CCEPs demonstrate systematic variability across trials and (2) CCEP amplitudes depend on the timing of stimulation with respect to endogenous, low-frequency oscillations.

Methods

We studied 11 patients who underwent CCEP mapping after stereo-electroencephalography electrode implantation for surgical evaluation of drug-resistant epilepsy. Evoked potentials were measured from all electrodes after each pulse of a 30 s, 1 Hz bipolar stimulation train. We quantified monotonic trends, phase dependence, an

SUBMITTER: Cornblath EJ 

PROVIDER: S-EPMC10480141 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature