[Progeroid syndromes : Aging, skin aging, and mechanisms of progeroid syndromes].

ABSTRACT: Progeroid syndromes (PSs) are characterized by the premature onset of age-related pathologies. PSs display a wide range of heterogeneous pathological symptoms that also manifest during natural aging, including vision and hearing loss, atrophy, hair loss, progressive neurodegeneration, and cardiovascular defects. Recent advances in molecular pathology have led to a better understanding of the underlying mechanisms of these diseases. The genetic mutations underlying PSs are functionally linked to genome maintenance and repair, supporting the causative role of DNA damage accumulation in aging. While some of those genes encode proteins with a direct involvement in a DNA repair machinery, such as nucleotide excision repair (NER), others destabilize the genome by compromising the stability of th

SUBMITTER: Koschitzki K 

PROVIDER: S-EPMC10480280 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature