Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real-world population-based cohort.

ABSTRACT:

Introduction

Plasma biomarkers-cost effective, non-invasive indicators of Alzheimer's disease (AD) and related disorders (ADRD)-have largely been studied in clinical research settings. Here, we examined plasma biomarker profiles and their associated factors in a population-based cohort to determine whether they could identify an at-risk group, independently of brain and cerebrospinal fluid biomarkers.

Methods

We measured plasma phosphorylated tau181 (p-tau181), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and amyloid beta (Aβ)42/40 ratio in 847 participants from a population-based cohort in southwestern Pennsylvania.

Results

K-medoids clustering identified two distinct plasma Aβ42/40 modes, further categorizable into three biomarker profile

SUBMITTER: Ferreira PCL 

PROVIDER: S-EPMC10480336 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature