⁶⁸Ga-bisphosphonates for the imaging of extraosseous calcification by positron emission tomography.

ABSTRACT: Radiolabelled bisphosphonates (BPs) and [¹⁸F]NaF (¹⁸F-fluoride) are the two types of radiotracers available to image calcium mineral (e.g. bone), yet only [¹⁸F]NaF has been widely explored for the non-invasive molecular imaging of extraosseous calcification (EC) using positron emission tomography (PET) imaging. These two radiotracers bind calcium mineral deposits via different mechanisms, with BPs chelating to calcium ions and thus being non-selective, and [¹⁸F]NaF being selective for hydroxyapatite (HAp) which is the main component of bone mineral. Considering that the composition of EC has been reported to include a diverse range of non-HAp calcium minerals, we hypothesised that BPs may be more sensitive for imaging EC due to their ability to b

SUBMITTER: Keeling GP 

PROVIDER: S-EPMC10480432 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature