Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway.

ABSTRACT: Bone remodeling is an extraordinarily complex process involving a variety of factors, such as genetic, metabolic, and environmental components. Although genetic factors play a particularly important role, many have not been identified. In this study, we investigated the role of transmembrane 161a (Tmem161a) in bone structure and function using wild-type (WT) and Tmem161a-depleted (Tmem161a^GT/GT) mice. Mice femurs were examined by histological, morphological, and bone strength analyses. Osteoblast differentiation and mineral deposition were examined in Tmem161a-overexpressed, -knockdown and -knockout MC3T3-e1 cells. In WT mice, Tmem161a was expressed in osteoblasts of femurs; however, it was depleted in Tmem161a^GT/GT mice. Cortical bone mineral density, thickness, and

SUBMITTER: Nagai T 

PROVIDER: S-EPMC10480474 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature