Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation.

ABSTRACT: Cell lines are valuable resources as model for human biology and translational medicine. It is thus important to explore the concordance between the expression in various cell lines vis-à-vis human native and disease tissues. In this study, we investigate the expression of all human protein-coding genes in more than 1,000 human cell lines representing 27 cancer types by a genome-wide transcriptomics analysis. The cell line gene expression is compared with the corresponding profiles in various tissues, organs, single-cell types and cancers. Here, we present the expression for each cell line and give guidance for the most appropriate cell line for a given experimental study. In addition, we explore the cancer-related pathway and cytokine activity of the cell lines to aid human biology studie

SUBMITTER: Jin H 

PROVIDER: S-EPMC10480497 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature