Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis.

ABSTRACT: Recently, large scale genomic projects such as All of Us and the UK Biobank have introduced a new research paradigm where data are stored centrally in cloud-based Trusted Research Environments (TREs). To characterize the advantages and drawbacks of different TRE attributes in facilitating cross-cohort analysis, we conduct a Genome-Wide Association Study of standard lipid measures using two approaches: meta-analysis and pooled analysis. Comparison of full summary data from both approaches with an external study shows strong correlation of known loci with lipid levels (R² ~ 83-97%). Importantly, 90 variants meet the significance threshold only in the meta-analysis and 64 variants are significant only in pooled analysis, with approximately 20% of variants in each of those groups be

SUBMITTER: Deflaux N 

PROVIDER: S-EPMC10480504 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature