Learning-dependent structural plasticity of intracortical and sensory connections to functional domains of the olfactory tubercle.

ABSTRACT: The olfactory tubercle (OT), which is a component of the olfactory cortex and ventral striatum, has functional domains that play a role in odor-guided motivated behaviors. Learning odor-guided attractive and aversive behavior activates the anteromedial (am) and lateral (l) domains of the OT, respectively. However, the mechanism driving learning-dependent activation of specific OT domains remains unknown. We hypothesized that the neuronal connectivity of OT domains is plastically altered through olfactory experience. To examine the plastic potential of synaptic connections to OT domains, we optogenetically stimulated intracortical inputs from the piriform cortex or sensory inputs from the olfactory bulb to the OT in mice in association with a food reward for attractive learning and electric

SUBMITTER: Sha MFR 

PROVIDER: S-EPMC10480507 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature