Changes in m⁶A RNA methylation of goat lung following PPRV infection.

ABSTRACT: Peste des petits ruminants (PPR) is an acute, highly contagious viral disease of goats and sheep, caused by the Peste des petits ruminants virus (PPRV). Earlier studies suggest the involvement of diverse regulatory mechanisms in PPRV infection. Methylation at N6 of Adenosine called m⁶A is a type RNA modification that influences various physiological and pathological phenomena. As the lung tissue represents the primary target organ of PPRV, the present study explored the m⁶A changes and their functional significance in PPRV disease pathogenesis. m⁶A-seq analysis revealed 1289 m⁶A peaks to be significantly altered in PPRV infected lung in comparison to normal lung, out of which 975 m⁶A peaks were hypomethylated and 314 peaks were hyperme

SUBMITTER: Nabi Khan RI 

PROVIDER: S-EPMC10480600 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature