Microenvironment-responsive Cu-phenolic networks coated nanofibrous dressing with timely macrophage phenotype transition for chronic MRSA infected wound healing.

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a pressing clinical issue that impedes wound healing. Pro-inflammatory M1 macrophages is required to clear bacteria and recruit various cell types during the initial phase of wound healing, but timing of this process is crucial. Herein, a microenvironment-responsive nanofibrous dressing capable of timely macrophage phenotype transition in vivo is constructed by coating copper ions (Cu²⁺)-polydopamine (PDA) networks on poly (ε-caprolactone) fiber (PCL-fiber) membrane. During the initial post-implantation period, the nanofibrous dressing show pH-sensitive Cu²⁺ release in the acidic infection microenvironment. The release Cu²⁺ have a direct killing effect on MRSA, and promote the pro

SUBMITTER: Xiao T 

PROVIDER: S-EPMC10480781 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature