Metabolomics analysis of MnO₂ nanosheets CDT for breast cancer cells and mechanism of cytotoxic action.

ABSTRACT: Chemodynamic therapy (CDT) has received more and more attention as an emerging therapeutic strategy, especially transition metals with Fenton or Fenton-like activity have good effects in CDT research, manganese dioxide nanosheets (MnO₂ NSs) and their complexes have become one of the most favored nanomaterials in CDT of tumors. CDT is mainly based on the role of reactive oxygen species (ROS) in tumor treatment, which have clear chemical properties and produce clear chemical reactions. However, their mechanism of interaction with cells has not been fully elucidated. Here, we performed CDT on mouse breast cancer cells (4T1) based on MnO₂ NSs, extracted the metabolites from the 4T1 cells during the treatment, and analyzed the differences in metabolites by using high-resol

SUBMITTER: Liu J 

PROVIDER: S-EPMC10481133 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature