A paintable and adhesive hydrogel cardiac patch with sustained release of ANGPTL4 for infarcted heart repair.

ABSTRACT: The infarcted heart undergoes irreversible pathological remodeling after reperfusion involving left ventricle dilation and excessive inflammatory reactions in the infarcted heart, frequently leading to fatal functional damage. Extensive attempts have been made to attenuate pathological remodeling in infarcted hearts using cardiac patches and anti-inflammatory drug delivery. In this study, we developed a paintable and adhesive hydrogel patch using dextran-aldehyde (dex-ald) and gelatin, incorporating the anti-inflammatory protein, ANGPTL4, into the hydrogel for sustained release directly to the infarcted heart to alleviate inflammation. We optimized the material composition, including polymer concentration and molecular weight, to achieve a paintable, adhesive hydrogel using 10% gelatin and

SUBMITTER: Lee M 

PROVIDER: S-EPMC10481188 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature