NHERF1/EBP50 immunoexpression in renal cell carcinomas and oncocytomas with ultrastructural analysis of clear cell renal cell carcinoma.

ABSTRACT:

Background

Na⁺/H⁺ exchanger (NHE) maintains the alkaline pH of epithelial cells working at the cellular membrane and exchanging H⁺/Na⁺ ions. In renal tubular epithelial cells, the reabsorption of NaCl is implemented by NHE3 isoform, which is regulated by NHE regulatory factor-1 (NHERF1). Normally situated at the apical zones of proximal tubular cells, NHERF1 participates in cytoskeletal reorganization and signal transduction facilitating structural stability and ion exchange. Based on an extensive search in English literature, NHERF1/EBP50 immunoexpression has been studied in breast, colon, and other tumors with only one study on 21 cases of renal cell carcinomas (RCC).

Methods

Using NHERF1/EBP50 immunohistochemistry (IHC) on 64 (8

SUBMITTER: Aksionau A 

PROVIDER: S-EPMC10481195 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature