Integrative analysis of deoxyribonuclease 1-like 3 as a potential biomarker in renal cell carcinoma.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC), the most common subtype of renal cell carcinoma (RCC), is insensitive to radiotherapy and chemotherapy after surgery. Deoxyribonuclease 1-like 3 (DNASE1L3), an endonuclease that cleaves both membrane-encapsulated single- and double-stranded DNA, suppresses cell cycle progression, proliferation and metabolism in hepatocellular carcinoma cells. There is currently no established link between DNASE1L3 and RCC inhibition. We are gonging to explored the mechanism underlying the relationship between DNASEL1L3 and RCC.

Methods

RNA sequencing data for RCC tissue and peritumoral tissue were downloaded from The Cancer Genome Atlas database and analyzed. The expression levels of DNASE1L3 in RCC and normal samples were verified using th

SUBMITTER: Ge M 

PROVIDER: S-EPMC10481204 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature