Identification of potential molecular mechanisms and therapeutic targets for recurrent pelvic organ prolapse.

ABSTRACT:

Background

The pathogenesis of recurrent pelvic organ prolapse (POP) is currently unclear. Therefore, developing targeted preventive measures is difficult. This study identified potential key pathways, crucial genes, comorbidities, and therapeutic targets associated with the occurrence and development of recurrent POP.

Methods

The original microarray data GSE28660, GSE53868, and GSE12852 were downloaded from the GEO database. Identification and validation of differentially expressed genes (DEGs) and hub genes associated with recurrent POP were performed using R software and cytoHubba of Cytoscape. Protein-protein interaction (PPI) networks were constructed using the STRING tool and visualized using Cytoscape. Gene ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC10481308 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature