Vaccines and the Risk of Hospitalization for Multiple Sclerosis Flare-Ups.

ABSTRACT:

Importance

Scientific literature is sparse about the association of vaccination with the onset of multiple sclerosis (MS) flare-ups. Immunization by vaccines of the entire population is crucially important for public health.

Objective

To evaluate the risk of hospitalization for severe MS flare-ups after vaccination in patients with MS.

Design, setting, participants

This cohort study included patients diagnosed with MS between January 1, 2007, and December 31, 2017, who were included in the System of National Health Databases, a national health claims database in France. In a nested case-crossover analysis, cases were defined by vaccine exposure prior to the onset of hospitalization due to an MS flare-up, and flare-up rates were compared with those that occurred prior

SUBMITTER: Grimaldi L 

PROVIDER: S-EPMC10481324 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature