Rapid Immunodot AQP4 Assay for Neuromyelitis Optica Spectrum Disorder.

ABSTRACT:

Importance

Immunoglobulin G autoantibodies for aquaporin 4 (AQP4-IgG) serve as diagnostic biomarkers for neuromyelitis optica spectrum disorder (NMOSD), and the most sensitive and specific laboratory tests for their detection are cell-based assays (CBAs). Nevertheless, the limited availability of special instruments limits the widespread use of CBAs in routine laboratories.

Objective

To validate an enzyme immunodot assay for simple and rapid detection of AQP4-IgG.

Design, setting, and participants

This multicenter case-control study, conducted from May 2020 to February 2023, involved 4 medical centers (3 in China and 1 in Korea). The study included patients with AQP4-IgG-positive NMOSD, patients with other immune-related diseases, and healthy control individuals. Part

SUBMITTER: Fu Y 

PROVIDER: S-EPMC10481325 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature