Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease.

ABSTRACT: Celiac disease (CD) is an autoimmune disease in which intestinal inflammation is induced by dietary gluten. The means through which gluten-specific CD4⁺ T cell activation culminates in intraepithelial T cell (T-IEL)-mediated intestinal damage remain unclear. Here, we performed multiplexed single-cell analysis of intestinal and gluten-induced peripheral blood T cells from patients in different CD states and healthy controls. Untreated, active, and potential CD were associated with an enrichment of activated intestinal T cell populations, including CD4⁺ follicular T helper (T_FH) cells, regulatory T cells (T_regs), and natural CD8⁺ αβ and γδ T-IELs. Natural CD8⁺ αβ and γδ T-IELs expressing activating natural killer cell receptor

SUBMITTER: Kornberg A 

PROVIDER: S-EPMC10481382 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature