Rising incidence and prevalence of systemic lupus erythematosus: a population-based study over four decades.

ABSTRACT:

Objectives

To determine the trends in incidence, prevalence and mortality of systemic lupus erythematosus (SLE) in a US population over four decades.

Methods

We identified all the patients with SLE in Olmsted County, Minnesota who fulfilled the European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria for SLE during 1976-2018. Age-specific and sex-specific incidence and prevalence rates were adjusted to the standard 2000 projected US population. The EULAR/ACR score was used as a proxy for disease severity. Standardised mortality ratio (SMR) was estimated.

Results

There were 188 incident SLE cases in 1976-2018 (mean age 46.3±SD 16.9; 83% women). Overall age-adjusted and sex-adjusted annual SLE incidence per 100 000 popul

SUBMITTER: Duarte-Garcia A 

PROVIDER: S-EPMC10481386 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature