Integrated transcriptomic and proteomic analyses of plerocercoid and adult Spirometra mansoni reveal potential important pathways in the development of the medical tapeworm.

ABSTRACT:

Background

Spirometra mansoni can parasitize animals and humans through food and water, causing parasitic zoonosis. Knowledge of the developmental process of S. mansoni is crucial for effective treatment; thus, it is important to characterize differential and specific proteins and pathways associated with parasite development.

Methods

In this study, we performed a comparative proteomic analysis of the plerocercoid and adult stages using a tandem mass tag-based quantitative proteomic approach. Additionally, integrated transcriptomic and proteomic analyses were conducted to obtain the full protein expression profiles of different life cycle stages of the tapeworm.

Results

Approximately 1166 differentially expressed proteins (DEPs) were identified in adults versus pleroc

SUBMITTER: Wang RJ 

PROVIDER: S-EPMC10481575 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature