An extended transcription factor regulatory network controls hepatocyte identity.

ABSTRACT: Cell identity is specified by a core transcriptional regulatory circuitry (CoRC), typically limited to a small set of interconnected cell-specific transcription factors (TFs). By mining global hepatic TF regulons, we reveal a more complex organization of the transcriptional regulatory network controlling hepatocyte identity. We show that tight functional interconnections controlling hepatocyte identity extend to non-cell-specific TFs beyond the CoRC, which we call hepatocyte identity (Hep-ID)^CONNECT TFs. Besides controlling identity effector genes, Hep-ID^CONNECT TFs also engage in reciprocal transcriptional regulation with TFs of the CoRC. In homeostatic basal conditions, this translates into Hep-ID^CONNECT TFs being involved in fine tuning CoRC TF expressio

SUBMITTER: Dubois-Chevalier J 

PROVIDER: S-EPMC10481658 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature