Mevalonate kinase gene polymorphisms in ankylosing spondylitis patients: A cross-sectional study.

ABSTRACT:

Objectives

This study aimed to investigate the potential effect of the mevalonate kinase (MVK) gene polymorphisms on the pathogenesis and clinical findings in ankylosing spondylitis (AS) patients.

Patients and methods

This cross-sectional study was conducted with 103 participants (63 males, 40 females) between January 2013 and January 2014. Of these, 51 (32 males, 19 females; mean age: 37.3±10.2 years; range, 19 to 60 years) were adult AS patients who met the 1984 Modified New York Criteria, and 52 (31 males, 21 females; mean age: 33.8±12 years; range, 19 to 60 years) were healthy volunteers with similar demographics. MVK gene analysis was performed using polymerase chain reaction sequencing by isolating deoxyribonucleic acids from peripheral blood samples. We determined ser

SUBMITTER: Yıldız F 

PROVIDER: S-EPMC10481690 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature