Atlas of gut microbe-derived products from aromatic amino acids and risk of cardiovascular morbidity and mortality.

ABSTRACT:

Aims

Precision microbiome modulation as a novel treatment strategy is a rapidly evolving and sought goal. The aim of this study is to determine relationships among systemic gut microbial metabolite levels and incident cardiovascular disease risks to identify gut microbial pathways as possible targets for personalized therapeutic interventions.

Methods and results

Stable isotope dilution mass spectrometry methods to quantitatively measure aromatic amino acids and their metabolites were used to examine sequential subjects undergoing elective diagnostic cardiac evaluation in two independent cohorts with longitudinal outcome data [US (n = 4000) and EU (n = 833) cohorts]. It was also used in plasma from humans and mice before vs. after a cocktail of poorly absorbed antibiotics to

SUBMITTER: Nemet I 

PROVIDER: S-EPMC10481777 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature