The comparable tumour microenvironment in sporadic and <i>NF2</i>-related schwannomatosis vestibular schwannoma.

ABSTRACT: Bilateral vestibular schwannoma is the hallmark of NF2-related schwannomatosis, a rare tumour predisposition syndrome associated with a lifetime of surgical interventions, radiotherapy and off-label use of the anti-angiogenic drug bevacizumab. Unilateral vestibular schwannoma develops sporadically in non-NF2-related schwannomatosis patients for which there are no drug treatment options available. Tumour-infiltrating immune cells such as macrophages and T-cells correlate with increased vestibular schwannoma growth, which is suggested to be similar in sporadic and NF2-related schwannomatosis tumours. However, differences between NF2-related schwannomatosis and the more common sporadic disease include NF2-related schwannomatosis patients presenting an increa

SUBMITTER: Gregory GE 

PROVIDER: S-EPMC10481781 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature