Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19.

ABSTRACT: Acute viral infections can have durable functional impacts on the immune system long after recovery, but how they affect homeostatic immune states and responses to future perturbations remain poorly understood^1-4. Here we use systems immunology approaches, including longitudinal multimodal single-cell analysis (surface proteins, transcriptome and V(D)J sequences) to comparatively assess baseline immune statuses and responses to influenza vaccination in 33 healthy individuals after recovery from mild, non-hospitalized COVID-19 (mean, 151 days after diagnosis) and 40 age- and sex-matched control individuals who had never had COVID-19. At the baseline and independent of time after COVID-19, recoverees had elevated T cell activation signatures and lower expression of innate immune g

SUBMITTER: Sparks R 

PROVIDER: S-EPMC10481789 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature