Differential genome-wide associated variants and enriched pathways of ECG parameters among people with versus without HIV.

ABSTRACT:

Objectives

People with HIV (PWH) are more likely to develop ECG abnormalities. Substantial evidence exists for genetic contribution to ECG parameters among general population. However, whether and how would host genome associate with ECG parameters among PWH is unclear. Our research aims to analyze and compare genetic variants, mapped genes, and enriched pathways of ECG parameters among PWH and HIV-negative controls.

Design

A cross-sectional study.

Method

We performed a large original genome-wide association study (GWAS) of ECG parameters among PWH ( n  = 1730) and HIV-negative controls ( n =  3746). Genome-wide interaction analyses were also conducted.

Results

A total of 18 novel variants were detected among PWH, six for PR interval including rs76345397 at ATL

SUBMITTER: He J 

PROVIDER: S-EPMC10481915 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature