Age and sex differences in the association between APOE genotype and Alzheimer's disease in a Taiwan Chinese population.

ABSTRACT:

Introduction

The Apolipoprotein E (APOE) epsilon (ε) 4 allele is a well-established risk factor for late-onset Alzheimer's disease (AD). Reports on white ancestry populations have showed that age, sex, and ethnicity have different effects on the association between APOE genotype and AD. However, studies on Asian populations such as Taiwan Chinese populations are limited. This study aimed to evaluate the association between APOE genotype and AD in a Taiwan Chinese population, and to explore if the association varies by age and sex.

Methods

We conducted a case-control study in 725 patients with AD and 1,067 age- and sex- matched controls without dementia from a Taiwan Chinese population. Logistic regression models were used to test the association between

SUBMITTER: Huang LC 

PROVIDER: S-EPMC10481952 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature