Dihydromyricetin supplementation improves ethanol-induced lipid accumulation and inflammation.

ABSTRACT:

Introduction

Excessive alcohol consumption leads to a myriad of detrimental health effects, including alcohol-associated liver disease (ALD). Unfortunately, no available treatments exist to combat the progression of ALD beyond corticosteroid administration and/or liver transplants. Dihydromyricetin (DHM) is a bioactive polyphenol and flavonoid that has traditionally been used in Chinese herbal medicine for its robust antioxidant and anti-inflammatory properties. It is derived from many plants, including Hovenia dulcis and is found as the active ingredient in a variety of popular hangover remedies. Investigations utilizing DHM have demonstrated its ability to alleviate ethanol-induced disruptions in mitochondrial and lipid metabolism, while demonstrating hepatoprotective acti

SUBMITTER: Janilkarn-Urena I 

PROVIDER: S-EPMC10481966 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature