Ontology highlight
ABSTRACT:
SUBMITTER: Herrera A
PROVIDER: S-EPMC10482005 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Herrera Antonio A Menendez Anghara A Ochoa Andrea A Bardia Lídia L Colombelli Julien J Pons Sebastian S
Development (Cambridge, England) 20230824 16
Here, we show that, in the developing spinal cord, after the early Wnt-mediated Tcf transcription activation that confers dorsal identity to neural stem cells, neurogenesis redirects β-catenin from the adherens junctions to the nucleus to stimulate Tcf-dependent transcription in a Wnt-independent manner. This new β-catenin activity regulates genes implicated in several aspects of contralateral axon growth, including axon guidance and adhesion. Using live imaging of ex-vivo chick neural tube, we ...[more]