Obesity exacerbates influenza-induced respiratory disease via the arachidonic acid-p38 MAPK pathway.

ABSTRACT: Obesity is a risk factor for severe influenza, and asthma exacerbations caused by respiratory viral infections. We investigated mechanisms that increase the severity of airway disease related to influenza in obesity using cells derived from obese and lean individuals, and in vitro and in vivo models. Primary human nasal epithelial cells (pHNECs) derived from obese compared with lean individuals developed increased inflammation and injury in response to influenza A virus (IAV). Obese mice infected with influenza developed increased airway inflammation, lung injury and elastance, but had a decreased interferon response, compared with lean mice. Lung arachidonic acid (AA) levels increased in obese mice infected with IAV; arachidonic acid increased inflammatory cytokines and inju

SUBMITTER: Chandrasekaran R 

PROVIDER: S-EPMC10482034 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature