High-resolution multi-shot diffusion imaging of structural networks in healthy neurocognitive aging.

ABSTRACT: Healthy neurocognitive aging has been associated with the microstructural degradation of white matter pathways that connect distributed gray matter regions, assessed by diffusion-weighted imaging (DWI). However, the relatively low spatial resolution of standard DWI has limited the examination of age-related differences in the properties of smaller, tightly curved white matter fibers, as well as the relatively more complex microstructure of gray matter. Here, we capitalize on high-resolution multi-shot DWI, which allows spatial resolutions < 1 mm³ to be achieved on clinical 3T MRI scanners. We assessed whether traditional diffusion tensor-based measures of gray matter microstructure and graph theoretical measures of white matter structural connectivity assessed by standard (1.5 m

SUBMITTER: Merenstein JL 

PROVIDER: S-EPMC10482115 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature