Identification of two distinct phylogenomic lineages and model strains for the understudied cystic fibrosis lung pathogen <i>Burkholderia multivorans</i>.

ABSTRACT: Burkholderia multivorans is the dominant Burkholderia pathogen recovered from lung infection in people with cystic fibrosis. However, as an understudied pathogen there are knowledge gaps in relation to its population biology, phenotypic traits and useful model strains. A phylogenomic study of B. multivorans was undertaken using a total of 283 genomes, of which 73 were sequenced and 49 phenotypically characterized as part of this study. Average nucleotide identity analysis (ANI) and phylogenetic alignment of core genes demonstrated that the B. multivorans population separated into two distinct evolutionary clades, defined as lineage 1 (n=58 genomes) and lineage 2 (n=221 genomes). To examine the population biology of B. multivorans, a represen

SUBMITTER: Parfitt KM 

PROVIDER: S-EPMC10482378 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature