Dynamic changes in macrophage subtypes during lung cancer progression and metastasis at single-cell resolution.

ABSTRACT:

Background

Lung cancer remains a major global health challenge. Macrophages (Macs) are one important component of tumor microenvironments (TMEs); however, their prognostic relevance to lung cancer is currently unknown due to the complexity of their phenotypes.

Methods

In the present study, reanalysis and atlas reconstruction of downloaded single-cell RNA sequencing (scRNAseq) data were used to systematically compare the component and transcriptional changes in Mac subtypes across different stages of lung cancer.

Results

We found that with the progression of lung cancer, the proportion of alveolar macrophages (aMacs) gradually decreased, while the proportions of Macs and monocytes (Monos) gradually increased, suggesting a chemotaxis process followed by a Mono-Mac diffe

SUBMITTER: Wang J 

PROVIDER: S-EPMC10482613 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature