Association between Childhood Asthma Control Test scores and lung pathophysiologic indicators in longitudinal measurements.

ABSTRACT:

Background

Childhood Asthma Control Test (C-ACT) is a well-validated questionnaire for asthma controls among 4-11 years old children. This study aims to examine if longitudinal C-ACT score changes could also reflect lung pathophysiologic changes.

Methods

Thirty-seven children (43% female) aged 5 to 10 years old with mild or moderate asthma were followed up for 6 weeks with bi-weekly assessments of C-ACT, airway mechanics, lung function and respiratory inflammation. Associations of longitudinal changes in C-ACT score with lung pathophysiologic indicators were evaluated using linear mixed-effects models.

Results

A two-point worsening of total C-ACT score (sum of child and caregiver-reported) was associated with significant decreases in forced expiratory volume during th

SUBMITTER: Cui X 

PROVIDER: S-EPMC10482637 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature