LTP induction by structural rather than enzymatic functions of CaMKII.

ABSTRACT: Learning and memory are thought to require hippocampal long-term potentiation (LTP), and one of the few central dogmas of molecular neuroscience that has stood undisputed for more than three decades is that LTP induction requires enzymatic activity of the Ca²⁺/calmodulin-dependent protein kinase II (CaMKII)^1-3. However, as we delineate here, the experimental evidence is surprisingly far from conclusive. All previous interventions inhibiting enzymatic CaMKII activity and LTP^4-8 also interfere with structural CaMKII roles, in particular binding to the NMDA-type glutamate receptor subunit GluN2B^9-14. Thus, we here characterized and utilized complementary sets of new opto-/pharmaco-genetic tools to distinguish between enzymatic and structural CaMKII

SUBMITTER: Tullis JE 

PROVIDER: S-EPMC10482691 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature