Dissecting human population variation in single-cell responses to SARS-CoV-2.

ABSTRACT: Humans display substantial interindividual clinical variability after SARS-CoV-2 infection^1-3, the genetic and immunological basis of which has begun to be deciphered⁴. However, the extent and drivers of population differences in immune responses to SARS-CoV-2 remain unclear. Here we report single-cell RNA-sequencing data for peripheral blood mononuclear cells-from 222 healthy donors of diverse ancestries-that were stimulated with SARS-CoV-2 or influenza A virus. We show that SARS-CoV-2 induces weaker, but more heterogeneous, interferon-stimulated gene activity compared with influenza A virus, and a unique pro-inflammatory signature in myeloid cells. Transcriptional responses to viruses display marked population differences, primarily driven by changes in cell abundan

SUBMITTER: Aquino Y 

PROVIDER: S-EPMC10482701 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature